EORTC-NCI-ASCO Annual Meeting on “Molecular Markers in Cancer”
From 27 October (afternoon) to 29 October 2011
with a tutorial from 25 October (evening) to 27 October (morning)
SQUARE - Brussels Meeting Centre, Glace Entrance, rue Mont des Arts, 1000 Brussels, Belgium
Contents
Tutorial
* Announcement
* Program
* Grant Application
* Challenges
Main Meeting
* Announcement
* Program
Accreditation
© www.atomium.be - SABAM 2011 - Amanito
Tutorial Program
From Hypothesis to Product: Diagnostic Development Tutorial
From Tuesday 25 to Thursday 27 October 2011
* The evening events (25 & 26 October) will take place at the RADISSON BLU ROYAL HOTEL (Click here for hotel site)
Tuesday 25 October 2011 (evening*)
SESSION 1 - Overview, General Principles & Clinical Scenarios
Chairs: Lisa McShane (US) & Sabine Tejpar (EU) |
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| 17:00 - 17:05 | Welcome & Overview of the Learning Objectives and Tutorial Schedule | L. McShane (US) |
| 17:05 - 17:35 | Translating Promising Assays into Clinical Practice: An overview of the Process | S. Taube (US) |
| 17:35 - 17:55 | Assay Standardization | F. Sweep (NL) |
| 17:55 - 18:25 | Introduction of the Clinical Scenarios and Assignment to Breakout Groups | S. Tejpar (BE) & R. Stupp (CH) |
| 18:25 - 19:10 | Walking Dinner | |
| 19:10 - 21:00 | Breakout Group Meetings Introductory Session 1 (Challenges) | Chairs |
Wednesday 26 October 2011 (morning)
SESSION 1 (Cont'd)
| 08:30 - 09:00 | Statistical Issues in Marker Development: Prognostic and Predictive Biomarkers | S. Hilsenbeck (US) |
| 09:00 - 09:30 | Multiplex Markers: Statistical Considerations in High-dimensional data and Pitfalls in the development of gene signatures | T. Gorlia (BE) |
| 09:30 - 10:00 | Statistical Design Issues: Randomized Trials with Biomarkers | L. McShane (US) |
| 10:00 - 10:15 | Coffee break | |
| 10:15 - 10:40 | Regulatory Issues (US) | R. L. Becker (US) |
| 10:40 - 11:05 | Regulatory Issues (EU) | F. Pignatti (UK) |
| 11:05 - 11:35 | Role of Predictive Markers in Optimizing Patient Selection for Treatment: Therapeutic Developer's Challenges | S. Khambata-Ford (US) |
| 11:35 - 11:40 | Identifying Needs Along the Development Path and Finding the Resources to Address Them | S. Taube (US) |
| 11:40 - 11:55 | Illustration from NCI | B. Conley (US) |
| 11:55 - 12:10 | Illustration from EORTC | N. Harbeck (DE) |
| 12:15 - 12:45 | Lunch |
Wednesday 26 October 2011 (afternoon)
SESSION 2 - Regulatory Issues and Identifying Resources
Stories of Success & Struggle
Chairs: Barbara Conley (US) & Steve Shak (US) |
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| 12:45 - 13:15 | Update on the BATTLE Study for Lung Cancer | E. Kim (US) |
| 13:15 - 13:25 | Identifying Prognostic Subgroups | S. Shak (US) |
| 13:25 - 13:35 | Diagnostic Approaches to Identify Predictive Subgroups | D. Rhodes (US) |
| 13:35 - 13:45 | Criteria for use of omics-based tests in clinical trials: NCI Update | L. McShane (US) |
| 13:45 - 14:05 | Discussion | |
| 14:05 - 14:45 | MGMT methylation , development of a predictive tool | M. Hegi & R. Stupp (CH) |
| 14:45 - 15:00 | Coffee Break | |
| 15:00 - 15:40 | FOCUS 3 and 4 trials in colorectal cancer: UK experience with trial design, biomarker validation, funding and tissue resources | T. Maughan & M. Parmar (UK) |
| 15:40 - 16:10 | Debate (Pitfalls in signature development) | S. Michiels (BE) |
| 16:10 - 18:10 | Breakout Group Meetings Introductory Session 2 (Challenges) | Chairs |
Wednesday 26 October 2011 (evening*)
SESSION 2 (Cont'd)
| 18:30 - 19:30 | Working Dinner | |
| 19:30 - 21:30 | Breakout Group Meetings Introductory Session 2 Cont'd (Challenges) | Chairs |
Thursday 27 October 2011 (morning)
SESSION 3 - Group Presentations
Chairs: Nadia Harbeck (EU) & Roger Stupp (EU) |
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| 07:00 - 08:30 | Breakout Group Meetings Introductory Session 3 (Challenges) | Chairs |
| 08:30 - 09:15 | Presentations and Development Plans: Challenge #1 | Rapporteur |
| 09:15 - 10:00 | Presentations and Development Plans: Challenge #3A | Rapporteur |
| 10:00 - 10:15 | Coffee break | |
| 10:15 - 11:00 | Presentations and Development Plans: Challenge #3B | Rapporteur |
| 11:00 - 11:45 | Presentations and Development Plans: Challenge #4 | Rapporteur |
| 11:45 - 12:10 | Feedback and Discussion | R. Stupp (CH) |
| 12:10 - 12:30 | Wrap Up Presentation | S. Tejpar (BE) |
| ADJOURN | ||
EORTC is partially supported by the Belgian National Lottery and by the Belgian Federal Science Policy Office