EORTC-58951-CLG

The value of 1) Dexamethasone vs prednisolone during induction 2) of prolonged versus conventional duration of L-Asparaginase therapy during consolidation and late intensification, in acute lymphoblastics leukemia and lymphoblastic non-Hodgkin lymphoma of childhood. A Randomised phase III study.
Study documentation
Trial StatusClosed for recruitment
DatesDate of activation: 08-Dec-98
Date Step1 close: 04-Aug-08
Data management at EORTCFull
Phase3
Randomized trialYes
TypeAdvanced
Targeted Sample size2000
Number of steps3
DrugMercaptopurine
Tioguanine
L-asparaginase
Cyclophosphamide
Cytarabine
Daunorubicin
Doxorubicin
Etoposide
Methotrexate
Methylprednisolone
Prednisolone
Vincristine
Vindesine
Dexamethasone
Pegaspargase
Study StaffJacques Otten
Study Coordinator - Universitair Ziekenhuis Brussel, Brussels
Stefan Suciu
Statistician - EORTC Headquarters, Brussels
Seraphine Rossi
Data Manager - EORTC Headquarters, Brussels
seraphine.rossi (at) eortc.be - +32 27741068
Gaetan de Schaetzen
Project Manager - EORTC Headquarters, Brussels
gaetan.deschaetzen (at) eortc.be - +32 27741618
Type of cancerAcute Lymphocytic Leukemia
Non Hodgkins Lymphoma
Participating GroupsEORTC Children's Leukemia Group(Coordinating Group)
Protocol summaryClinicalTrials.gov
NCT numberNCT00003728
EudraCT